丙戊酸钠用药差错致肝损伤:病例分析
投稿时间:2019-02-21  修订日期:2019-05-22  点此下载全文
引用本文:周婷,蔡建,段晶晶,刘芬莲,胡芳宝,陆赛花.丙戊酸钠用药差错致肝损伤:病例分析[J].药学实践杂志,2019,37(5):466~469
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作者单位E-mail
周婷 上海市奉贤区中心医院药剂科, 201499 上海  
蔡建 上海市奉贤区精神卫生中心医务科, 201499 上海  
段晶晶 上海市奉贤区中心医院药剂科, 201499 上海  
刘芬莲 上海市奉贤区中心医院重症监护室, 201499 上海  
胡芳宝 上海市奉贤区中心医院重症监护室, 201499 上海  
陆赛花 上海市奉贤区中心医院药剂科, 201499 上海 lusaihua9671@163.com 
基金项目:上海市临床药学重点专科建设项目(2018~2020);上海市奉贤区卫计委联合项目(20161120)
中文摘要:目的 从1例脑卒中后继发癫痫患者丙戊酸钠用药错误的处置过程,探讨医疗团队中临床药师在纠正治疗用药错误中的作用。方法 临床药师参与丙戊酸钠用药错误处置的全程治疗,向临床宣教血药浓度监测、丙戊酸钠合理用药(剂量和用法),以及最常见的不良反应和潜在的药物相互作用。结果 患者抽搐症状得以控制,丙戊酸钠引起肝损伤得以恢复。结论 临床药师参与药物治疗,既要关注正常用法、用量下的药物不良反应,也应具有处置用药错误的能力,充分发挥临床药师的专业作用。
中文关键词:丙戊酸钠  肝损伤  治疗药物监测  临床药师
 
Liver damage caused by sodium valproate medication error: a case report
Abstract:Objective To analyze the participation effect of clinical pharmacist during the treatment process of sodium valproate in a patient with secondary epilepsy after stroke.Methods The correct dose and usage of sodium valproate under TDM,the most common ADR and the potential DI were introduced by clinical pharmacists who participated in the whole course treatment of sodium valproate.Results The convulsion was controlled and the liver damage caused by sodium valproate was recovered.Conclusion Clinical pharmacist should not only pay attention to ADRs under normal usage and dosage,but also pay special attention to the ability to deal with drug errors,so as to promote rational and individualized drug use.
keywords:sodium valproate  liver damage  therapeutic drug monitoring (TDM)  clinical pharmacist
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